|(6S,8S,10S,11S,13S,14S,16S,17R)-6,9-二氟-11,17-二羟基-17-(2-羟基乙酰基)-10,13,16-三甲基-6,7,8,9,10,11,12,13,14,15,16,17-十二氢-3H-环戊并[a]菲-3-酮|CsnPharm

CAS No.: 2557-49-5

二氟拉松 Catalog No. CSN23253

Synonyms: Florone;Maxiflor;U-34865

Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin, which can reduce production of the inflammatory cytokines Il-6, Il-4, and macrophage inflammatory protein-2 (Mip-2).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm^[1]. 0.05% diflorasone diacetate cream was as effective as 0.05% fluocinonide cream in the therapy of lesions of psoriasis or atopic/neurodermatitis^[2]. Diflorasone inhibits RANTES and thymus and activation regulated chemokine (TARC) in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis^[3]. It also inhibits proliferation of human keratinocytes in vitro and reduces epidermal thickening in a mouse model of psoriasis induced by imiquimod^[4].
参考文献

[1] Wickrema Sinha AJ, Shaw SR, Weber DJ. Percutaneous absorption and excretion of tritium-labeled diflorasone diacetate, a new topical corticosteroid in the rat, monkey and man. J Invest Dermatol. 1978 Dec;71(6):372-7
[2] Bluefarb SM, Howard FM, Leibsohn E, Schlagel CA, Wexler L. Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. J Int Med Res. 1976;4(6):454-61
[3] Bäumer, W., Seegers, U., Braun, M., et al. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Br. J. Dermatol. 2004; 151(4): 823-830
[4] Schaper, K., Dickhaut, J., Japtok, L., et al. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J. Dermatol. Sci. 2013; 71(1): 29-36 (2013).

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4363 mL
- 12.1817 mL
- 24.3634 mL
- 5 mM
- 0.4873 mL
- 2.4363 mL
- 4.8727 mL
- 10 mM
- 0.2436 mL
- 1.2182 mL
- 2.4363 mL

技术信息

CAS号

2557-49-5

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H28F2O5

运输

蓝冰

分子量

410.45

别名

Florone;Maxiflor;U-34865;二氟拉松

溶解度

DMSO	320.0 mg/mL (779.6 mM)
Water	insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

二氟拉松 Catalog No. CSN23253

靶点选择性

请登录您的专属账户

确认信息